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KMID : 1145120170150010105
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Asian Journal of Beauty and Cosmetology
2017 Volume.15 No. 1 p.105 ~ p.111
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Photoprotective Effects of Caffeic Acid against Ultraviolet-induced Damages on Human Follicle Dermal Papilla Cells
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Ahn Kyu-Joong
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Abstract
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Purpose: Caffeic acid is one of anti-oxidant phenolic acids and is abundant in plants and algae. Various reports have shown that caffeic acid inhibits ultraviolet (UV)-induced matrix metalloproteinase 1 upregulation and skin carcinogenesis, however, the photoprotective effects on human follicle dermal papilla cells (HFDPCs) have not been elucidated yet.
Methods: We investigated if caffeic acid inhibits UV-induced cellular damages in HFDPCs by conducting cell viability, UV protection, intracellular reactive oxygen species (ROS), and cellular senescence detection assays.
Results: We found that caffeic acid had a low cytotoxicity and significantly inhibited UVB-induced cytotoxicity on HFDPCs. In addition, treatment with caffeic acid decreased UVB-mediated intracellular ROS production in a dose-dependent manner. Furthermore, UVB-induced cellular senescence, which was detected by a senescence-associated β-galactosidase (SA-β-galactosidase) assay, markedly reduced in caffeic acid treatment before UVB irradiation on HFDPCs.
Conclusion: Our data indicated that caffeic acid has protective effects against UVB-induced cellular damages on HFDPCs.
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KEYWORD
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Caffeic acid, Human follicle dermal papilla cell, Ultraviolet, Protection, Senescence
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